Mesothelioma is a rare cancer that occurs almost entirely caused by exposure to asbestos. Because there is no cure for this disease, life expectancy for most mesothelioma patients ranged between four and 18 months after diagnosis of mesothelioma is known for sure. Although there is no cure to date, some patients who are diagnosed early mesothelioma can be given a combination of aggressive therapy, such as surgery, chemotherapy and radiation. Combination therapy, which is known as a multimodality therapy, currently has the best chance to extend the life of the patient.
Mesothelioma malignant cells
The study's authors explained, "Gene methylation led to the development of malignant tumors in several tumor [malignant mesothelioma] are histologically divided into three subtypes, namely, epithelioid, sarcomatoid and biphasic types, and it shows that mesothelin expression is restricted to epithelioid type and the epithelioid component of biphasic MM type (malignant mesothelioma). However, the mechanism of expression regulation has not been clarified. "
Asbestos Pipe workers at high risk for Mesothelioma
A total of 118 lung specimens examined, including 39 MM, 41 lung carcinomas, 26 nonneoplastic lung lesions, and 12 samples of normal lung tissue. Specimens were tested for mesothelin expression by immunohistochemistry test, along with the methylation status of 20 locations mesothelin gene promoter.
The results showed mesothelin is expressed in the epithelioid subtype of epithelioid and biphasic subtypes. However, the expression of mesothelin is not found in either the subtype of sarcomatoid or sarcomatous part of the biphasic type. Mesothelin gene promoter have a significantly hypomethylasi on mesotehelioma malignant specimens without subtype when compared with other lung lesions and lung tissue samples to normal.
The risk of asbestos industry workers
The researchers concluded, "These findings suggest that hypomethylasi of mesothelin gene promoter may be specifically associated with the formation of MM, regardless of expression status, and that the mesothelin protein expression is lost in the sarcomatoid type due to some posttranscriptional regulatory mechanisms are unknown. "
Reference: jevuska[dot]com
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