Monday, September 12, 2011

Mesothelioma: Clinical and Morphology

Tumor cells are rarely found mesotelial is most common in the pleura (more rarely in the peritoneum and other places). Mesothelioma is a tumor associated with asbestos exposure in the workplace in 90% of cases; however. only 20% of all patients who suffered from pulmonary asbestosis. The risk of life (not influenced by smoking habits) in patients with severe exposure is 7-10% with a latent period between exposure and onset of tumor-25-45 years. Among the asbestos factory workers, lung carcinoma remains the most frequent tumor found; risk of lung carcinoma experienced a noticeable increase if there is also the habit of smoking.
 Clinical Overview
 Mesothelioma patients found with chest pain, dyspnea and recurrent pleural effusions. Highly malignant mesothelioma is a tumor that invades the lungs and can metastasize widely. Some patients with these tumors can survive more than 2 years.
 Menyehar tumors are diffuse pulmonary fissures on the surface and forming a sheath that surrounds the tumor. Epitelioid microscopic patterns of tumor (70%), sarkomatoid (20%) and mixed (biphasic) (10%).
 • The pattern shows epitelioid-cell-like epithelial cells by forming tubular and papillary protrusions that resemble adenocarcinoma. ¬ characterize antigenic characteristics (kalretinin, WT-1 positivity and CK5 / 6) and ultrastructural (microvilli are long and slender) allows these tumors be distinguished with adenocarcinoma (MOC3I positivity and BG8 and have short microvilli and fat).
 • Polo sarkomatoid showed malignant cells resembling fibrosarcoma-shaped coil.


Mesothelioma: Clinical and Morphology

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